Caveolin-1 is associated with acquired selumetinib resistance and altered EGFR signaling in colorectal cancer cells.
Acquired resistance remains a major limitation to the sustained efficacy of mitogen-activated protein kinase kinase (MEK) inhibition in colorectal cancer (CRC), but the molecular adaptations associated with this phenotype remain incompletely defined. This pilot study investigated the association of Caveolin-1 with acqu...