H. Fuchs

Antibacterial activity and mechanistic insights into para-substituted triphenylphosphonium salts.

Dodecyl- and tetradecyl-substituted triphenylphosphonium (TPP) derivatives (1d and 1e) were previously identified by our group as potent antimicrobials, although their mammalian cytotoxicity and hemolytic activity limited their therapeutic potential. To mitigate these drawbacks, six novel para-substituted TPP derivativ...