DNA topoisomerase II (Topo II) is essential for maintaining DNA topology during replication, transcription, and chromosome segregation. Its increased expression is associated with tumor progression, which makes it an appealing target for anticancer therapy. However, clinically used Topo II inhibitors such as etoposide...
Essam A. Ali, A. Sarhan, Nesreen S. Ahmed et al.· Scientific Reports· 0 citations
Multi-target drugs possess significant therapeutic potential for the therapy of complex diseases and drug-resistant conditions. Based on this fact, isatin-pyrazole derivatives, namely, 5-substituted isatin-pyrazole derivatives 7a-d and N-alkyl isatin-pyrazole derivatives 9a-d, were prepared by merging the pyrazole moti...
Mohamed A. Al-Omar, H. Alkahtani, M. A. Bhat et al.· Bulletin of the Chemical Soc...· 0 citations
A new series of quinoline-diphenylpyrazole hybrids were rationally designed, synthesized, and biologically evaluated as potential EGFR/VEGFR-2/COX-2 inhibitors, supporting the proposed hybrid design strategy.
Abdelrahman Hamdi, Mohamed R. Elnagar, M. Hussein et al.· Bioorganic chemistry (Print)· 0 citations
A novel series of benzofuran-based aryl urea derivatives incorporating a 1,3,4-thiadiazole linker were designed as dual VEGFR-2/BRAFWT inhibitors using sorafenib as a pharmacophoric template, with compound 7j emerging as the most active analogue.
Marwa I. Serag, Mohamed R. Elnagar, Wafaa A. Ewes et al.· Bioorganic & Medicinal Chemi...· 1 citation
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