Author

H. Guchelaar

h-index 39 View on Semantic Scholar

We have 3 of 213 papers

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Open access Sep 2026

DPYD c.85T>C, DPYD c.496A>G, and DPYD c.2194G>A and severe toxicity to fluoropyrimidines in PREPARE and Alpe-DPD trials. An original study and meta-analysis.

Current DPYD genotyping panels used to prevent fluoropyrimidine (FL)-related toxicity explain only a limited proportion of severe adverse events. The clinical relevance, beyond current testing, of additional DPYD variants, including DPYD⁎6 (c.2194G>A, rs1801160), DPYD c.496A>G (rs2297595), and DPYD⁎9A (c.85T>C, rs18012...

E. De Mattia, J. Polesel, M. van der Lee et al. · Pharmacological Research · 0 citations

Open access Sep 2026

From Clinical Trials to Real-World Patients: Population Pharmacokinetics and Precision Dosing Simulations of Lorlatinib.

Simulations suggest that lower lorlatinib doses may be feasible and MIPD may reduce toxicity, underscoring the importance of external validation of clinical trial-derived models.

L. Bukkems, Benoit Blanchet, J. Arrondeau et al. · Clinical Pharmacokinetics · 0 citations

Review Jul 2026

Validation of a Text-Mining Tool for Extracting Routine Clinical Care Data in Early-Stage Resectable Non-Small Cell Lung Cancer.

CTcue performance for patient selection was lower than anticipated, however, it enables accurate, efficient extraction of structured and unstructured EHR data in early-stage NSCLC.

Hanieh Abedian Kalkhoran, Tobias Martinot, Lydia H N Schonewille et al. · JCO Clinical Cancer Informat... · 0 citations