Author

H. Hase

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Open access Sep 2026

An ALKBH3 Inhibitor HUHS199 Suppresses Proliferation of Glioblastoma Cells by Targeting 1‐Methyladenosine on GADD45A mRNA

Glioblastoma (GBM) is a highly aggressive, poor‐prognosis brain tumor classified as WHO grade IV, for which effective treatments remain limited. Although AlkB homolog 3 (ALKBH3), a demethylase for 1‐methyladenosine (m1A) and 3‐methylcytidine (m3C) in DNA and RNA, has been implicated in cancer cell proliferation, its fu...

Manami Yamada, H. Hase, Honoka Kitamura et al. · Chemical Biology and Drug De... · 0 citations

Open access Jul 2026

Integrated multi-omics analysis reveals a pH-driven metabolic and translational switch in Ureaplasma parvum

ABSTRACT Human ureaplasmas are minimal-genome bacteria and pathobionts of the urogenital tract. They must adapt to fluctuating pH conditions despite the absence of canonical transcriptional regulatory systems. However, the mechanisms underlying these responses remain unclear. This study aimed to construct a system-leve...

H. Hase, Y. Nakura, Yuki Shimada et al. · Microbiology spectrum · 0 citations