H. Heerklotz

Revisiting the mode of action of daptomycin considering the inoculum effect and a novel liposome-MIC-competition assay.

Daptomycin (DAP) is a cyclic lipopeptide drug for intravenous application against Gram-positive bacteria such as methicillin-resistant Staphylococcus aureus (MRSA). In spite of numerous studies, its mode of action remains controversial. This is partially due to the fact that no attention has been paid to the strong dep...