Metastatic renal cell carcinoma (RCC) remains a lethal malignancy, and therapeutic resistance to current targeted and immune-based therapies highlights the need for new treatment strategies. Here, we identify C18-epi-brasilibactin A (CBA) as a selective inhibitor of RCC. High-throughput screening of a compound library...
Ara Jo, Sanjeevram Dhandapani, Zi-Qin Wang et al.· Molecular Therapy· 0 citations
It is found that RUNX1T1 is essential for SCNPC survival, as its knockdown induced apoptotic cell death and the acquisition of PRAD-like identity, including alterations in genes involved in cell-cell adhesion and epithelial cell polarity are found.
Zi-Qin Wang, H. Jung, Changhyeon Hong et al.· Frontiers in Cell and Develo...· 0 citations
It is demonstrated that DNMT3B is required for both the initiation and maintenance of the NEPC phenotype, and its inhibition suppresses NEPC growth and differentiation, highlighting it as a promising therapeutic target for treatment-resistant disease.
Yunsol Jo, H. Jung, Zi-Qin Wang et al.· Molecular Cancer Research· 0 citations
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