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H. Kletzien

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Open access Jul 2026

In vivo gene disruption and homology-directed repair in muscles and muscle stem cells using CRISPR/Cas9

It is found that postnatal cardiac muscle, skeletal muscle, and muscle stem cells undergo templated HDR at different rates across discrete developmental stages in mice, and in neonatal mice, editing in neonatal mice yielded more efficient HDR in cardiac tissue.

Bryan L. Peacker, Kuan-Hung Lin, A. Lam et al. · 0 citations