Author

H. Klümpen

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Open access Oct 2026

Adjuvant chemotherapy with cisplatin and gemcitabine compared to standard of care after curative intent resection of cholangiocarcinoma and muscle invasive gallbladder carcinoma (ACTICCA-1/AIO-HEP-0112 trial).

BACKGROUND Despite curative resection and adjuvant capecitabine, about 50% of biliary tract cancer (BTC) patients have tumour recurrence or die within two years. Combination chemotherapy with cisplatin and gemcitabine (CisGem) is an established palliative chemotherapy regimen BTC, which has been evaluated in the adjuva...

A. Stein, J. Bridgewater, H. Klümpen et al. · Annals of Oncology · 0 citations

Open access Aug 2026

Chronic liver disease is associated with earlier-stage cholangiocarcinoma diagnosis and improved prognosis: Findings from the GLOBAL-BTC registry.

Pre-existing CLD is associated with earlier-stage CCA diagnosis and improved survival, supporting the implementation of structured surveillance strategies in high-risk CLD populations and highlighting the need to optimize strategies for selected moderate-to-high risk CLD populations.

L. Izquierdo-Sánchez, J. Narbaiza, Julen Martin-Robles et al. · Journal of Hepatology · 0 citations