PURPOSE
To examine the relationship between brain mu opioid receptor (MOR) availability and liver activity in opioid use disorder (OUD) patients treated with methadone (MET) or buprenorphine (BUP).
METHODS
10 OUD patients, 5 treated with MET and 5 with BUP, as well as 13 healthy controls (HCs) underwent total-body PE...
Elizabeth J. Li, C. Wiers, Chia-Ju Hsieh et al.· European Journal of Nuclear...· 0 citations
Summary Paragraph Personality traits describe stable differences in how people think, feel, and behave and how they interact with and experience their social and physical environments1,2. Many questions remain unanswered about associations between DNA and personality traits, such as their robustness, generalizability,...
T. Schwaba, Margaret L. Clapp Sullivan, W. Akingbuwa et al.· Nature· 5 citations· ⚡1
In this sample, ADHD was associated with increased risk for SUDs and earlier onset of substance use and genetic liability to ADHD was independently associated with multiple SUDs and SUD criteria counts.
Michael R. Setzer, R. Kember, Emily E. Hartwell et al.· Psychological Medicine· 0 citations
In both AFR and EUR, environmental factors explained most of the variance in AUD criterion count, but polygenic risk was also a statistically significant predictor, and the pattern of results for OUD was similar.
P. Na, J. Deak, D. Levey et al.· International Journal of Neu...· 0 citations
These findings expand the known genetic architecture of migraine across ancestries and provide a genetics-led map connecting association signals with biological pathways, multimorbidity and candidate therapeutic mechanisms, providing a foundation for future functional and translational studies.
C. Overstreet, M. Galimberti, K. Harsan et al.· medRxiv· 0 citations
OBJECTIVE
Suicidal ideation (SI) and suicide attempt (SA) are both influenced by genetic, behavioral, and environmental factors. Alcohol use disorder (AUD) and adverse childhood experiences (ACEs) may mediate or moderate the effects of genetic liability for suicidality.
METHODS
Using data from 10,275 participants (43...
V. Wu, X. Qin, A. Ashley-Koch et al.· Journal of Affective Disorde...· 0 citations
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