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Author

H. Kurasawa

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Open access Aug 2026

Sequence-intrinsic barriers define a class of translation-restricted uORFs in the human genome

This work systematically quantified the intracellular accumulation of 111 evolutionarily conserved human uORFps and identified a conserved class of human uORFs that encode intrinsic barriers to productive translation and provide a rigorous framework for understanding how noncanonical coding sequences shape the human proteome.

Hinata Hashimoto, Taichi Akase, H. Kurasawa et al. · 0 citations

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