Anterior insular cortex neurostimulation modulates sensory hypersensitivity and pain-related emotional behaviors in a rat model of chronic neuropathic pain.
BACKGROUND AND AIMS Chronic neuropathic pain (NP) is frequently accompanied by anxiety- and depression-like behaviors that contribute to functional impairment. The insular cortex plays a central role in pain processing and interoceptive regulation, with the anterior insular cortex (AIC) critically involved in integrati...