Open access
Sep 2026
Delayed B-cell reconstitution in the bone marrow precedes the development of chronic graft-versus-host disease following pediatric hematopoietic stem cell transplantation
Introduction Allogeneic hematopoietic stem cell transplantation (HSCT) in children remains challenged by chronic graft-versus-host-disease (cGvHD), significantly affecting morbidity and survival. While aberrant peripheral B-cell reconstitution has been implicated in cGvHD, B-cell development in the bone marrow (BM) rem...
Elisa Christine Nimskov-Peen, K. Müller, K. Kielsen et al.
· Frontiers in Immunology · 0 citations