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Author

H. Metwally

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Aug 2026

Identification of a regulatory allosteric site in Arid5a unveils a therapeutic axis for systemic inflammation.

Adenine-thymine (AT)-rich interactive domain-containing protein 5a (Arid5a) is an RNA-binding protein (RBP) that post-transcriptionally stabilizes mRNAs encoding proinflammatory mediators, including Interleukin-6 (IL-6), thereby amplifying inflammation. However, structural basis and regulatory mechanisms of Arid5a func...

Hamza Hanieh, H. Metwally, Tadamitsu Kishimoto · 0 citations

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