Author

H. Mikolajek

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Open access Jul 2026

Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy

It is established that HCM-linked ACTN2 variants compromise protein integrity through multiple mechanisms, highlight the ABD as a hotspot of vulnerability and provide a potential framework for interpreting cardiomyopathy-associated variants.

Maya Noureddine, H. Mikolajek, Nathan Cowieson et al. · Nature Communications · 0 citations

Open access Jul 2026

AI-assisted fragment-based drug discovery of SARS-CoV-2 macrodomain binders validated by NMR and X-ray crystallography.

This study demonstrates the advantages of integrating AI with FBDD to streamline molecular design, providing a data-driven framework for discovering new Mac1 inhibitors and guiding future antiviral drug development.

Elnaz Aledavood, Sandra Ramos-Inza, Jannis Born et al. · Communications Chemistry · 0 citations