Author

H. Mulder

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Open access Nov 2026

Identifying novel genomic alterations in relapsed childhood B-ALL: a report from the Children's Oncology Group.

Relapsed B-acute lymphoblastic leukemia (B-ALL) generally occurs due to the emergence of subclones resistant to therapy, leading to poor outcome. Here, we describe novel genomic alterations responsible for therapeutic resistance at a subtype level in a clinical trial (AALL1331) which randomized patients to blinatumomab...

Yuan Feng, Han-Xia Li, H. Mulder et al. · Blood · 0 citations

Open access Sep 2026

Tumor gasdermin E acts as a rheostat to limit apoptotic cell survival and mutagenesis in anticancer immune environments

Recent studies have described an ability of cancer cells to survive engagement of apoptotic pathways following chemical and therapeutic insults, challenging the prevailing model that caspase activation inevitably leads to cellular demise. Gasdermin E (GSDME), whose expression is frequently down-regulated or silenced in...

Bei-Yun C. Liu, Suresh Poudel, X. Zhang et al. · Science Advances · 0 citations