Pancreatic ductal adenocarcinoma (PDAC) with anaplastic features is a rare and highly aggressive subtype with an extremely poor prognosis. However, the molecular mechanisms underlying anaplastic transformation remain poorly understood. To characterize the anaplastic transformation molecular landscape, we analyzed genom...
Akimasa Hayashi, Shota Sasagawa, Takahiro Shibayama et al.· Journal of Pathology· 0 citations
Thymic epithelial cells (TECs) play a vital role in the generation of immunocompetent and immunotolerant T cells. The understanding of TEC biology in model animals such as mice has advanced thanks to the cellular and molecular analyses of purified TEC populations, including cortical TECs (cTECs) and medullary TECs (mTE...
Naoko Matsui, H. Kondo, K. Maejima et al.· JIM - Journal of Immunologic...· 0 citations
Some patients with diabetic kidney disease (DKD) experience rapid loss of kidney function despite minimal proteinuria; however, the cellular and pathological features associated with this phenotype remain unclear. In this study, we aimed to characterize the cell-specific transcriptional and pathological alteratio...
Shunichiro Tsukamoto, Ryosuke Jikuya, H. Wakui et al.· Cardiovascular Diabetology· 0 citations
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