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Sep 2026

In-depth comparison of dengue virus laboratory strains and clinical isolates in terms of growth properties and NS1 production and detection in hepatic and non-hepatic cell lines.

Dengue virus (DV) is a major arboviral pathogen, with the liver being a primary target organ. The viral non-structural protein-1 (NS1) plays important roles in replication, autoimmunity, and pathogenesis, but strain-specific differences in NS1 secretion and cell responses remain incompletely understood. In this study,...

Chiroshri Dutta, H. Nath, K. Basu et al. · 0 citations
Review Open access Aug 2026

NS-segment-based reporter influenza A viruses: engineering strategy, applications, and limitations

ABSTRACT Reporter-expressing recombinant influenza A viruses (IAVs) have emerged as powerful tools for studying viral infection, host–pathogen interactions, and the identification and characterization of prophylactic and/or therapeutic countermeasures for the treatment of IAV infections. By incorporating a reporter gen...

Ramya S. Barre, H. Nath, A. Nogales et al. · 0 citations
Open access Aug 2026

A One-Shot Multivalent Live-Attenuated Candidate Influenza Vaccine against Divergent Zoonotic H5N1 Clades

The development and implementation of this multivalent LAIV as a broadly protective pan-H5N1 LAIV for pandemic preparedness are supported and the feasibility of developing and implementing this multivalent LAIV as a broad protective pan-H5N1 LAIV against divergent H5N1 viruses for human use is demonstrated.

Ahmed M. Elsayed, Ramya S. Barre, Arash Rahmani et al. · 0 citations

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