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Author

H. Phatnani

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Open access Sep 2026

Fibronectin mediates APOE4-driven blood–brain barrier dysfunction in Alzheimer’s disease

Blood–brain barrier (BBB) dysfunction is an early feature of Alzheimer’s disease (AD) and is particularly pronounced in individuals carrying the APOE ε4 allele, but the mechanisms linking APOE ε4 to BBB failure remain unclear. Here we show that astrocyte-derived fibronectin (FN1) is a key mediator of apolipoprotein E4...

P. Bhattarai, E. Yılmaz, Elif Öykü Cakir et al. · 1 citation
Open access Aug 2026

Distinct Cellular Phenotypes of Language and Executive Decline in Amyotrophic Lateral Sclerosis

It is uncovered that cognitive impairment in ALS is associated with distinct patterns of neuronal dysfunction and glial-vascular dysregulation that vary by region and cognitive subtype, and clinical heterogeneity in ALS is driven by phenotype-specific cellular interactions in motor and non-motor regions of the brain.

J. Petrescu, Cláudio Gouveia Roque, Chris Jackson et al. · 0 citations

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