AQbD-based development and validation of an HPLC–PDA method for simultaneous determination of sibutramine, desmethylsibutramine, and didesmethylsibutramine in herbal weight-loss supplements
Illegal adulteration of herbal weight-loss supplements with sibutramine (SIB) and its structurally related analogues remains a significant public health concern, highlighting the need for reliable, accessible, and cost-effective analytical methods for routine regulatory surveillance. In this study, a high-performance l...