Author

H. Rühl

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Open access Jul 2026

In vivo and ex vivo impact of THBD and PROCR polymorphisms on the anticoagulant response of the protein C pathway.

In vivo evidence is provided that common THBD and PROCR variants modulate PC pathway function, establishing the APC response as a sensitive endpoint for subtle genetic effects beyond FVL and not associated with THBD 1418C>T.

S. Reda, N. Schwarz, Sebastian Eckert et al. · Blood Advances · 0 citations

Open access Aug 2026

AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins

This work presents a scalable mammalian cell-display workflow to identify AI-designed minibinders against cancer surface targets and identifies biochemical optimization beyond the binding interface as a critical requirement for translating AI-minibinders into functional applications.

B. Broske, B. McEnroe, S. C. Frechen et al. · Nature Communications · 1 citation