Author

H. S. Hillen

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Open access Sep 2026

Structure of the human mitochondrial RNA degradosome reveals a distinct mode of helicase–nuclease coupling

RNA degradation shapes cellular and organellar gene expression. In human mitochondria, this process is mediated by a dedicated degradosome comprising the helicase SUV3 and the exoribonuclease PNPase, but how these enzymes assemble and cooperate to degrade structured RNA has remained unknown. Here, we report the cryo-EM...

P. F. V. Do Prado, Saruby Sharma, Arjun Bhatta et al. · bioRxiv · 0 citations

Review Open access Jul 2026

Structure and dynamics of the Nipah virus RNA-dependent RNA polymerase.

How snapshots of the NiV RdRp complex in precatalytic, early-elongation, and inhibitor-bound states shed light on the molecular mechanisms of RNA synthesis and inhibition in NiV is reviewed and how these insights expand the understanding of nsNSV RdRps in general is explored.

Fernanda A. Sala, H. S. Hillen · TIBS -Trends in Biochemical... · 0 citations