Author

H. Satake

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Open access Sep 2026

A Practical Workflow for Reliable MALDI-Based Hydrogen/Deuterium Exchange Mass Spectrometry

Matrix-assisted laser desorption/ionization-based hydrogen/deuterium exchange mass spectrometry (MALDI-HDX-MS) can provide peptide-level information on protein conformational dynamics without any specialized liquid chromatography (LC)-HDX instrumentation. Accurate interpretation of structure-dependent deuterium incorpo...

Tatsuya Yamamoto, H. Satake · Mass Spectrometry · 0 citations

Review Open access Jul 2026

Exploration peptide-GPCR specificity beyond homology and tertiary structure: computational insights into deorphanization and molecular mechanisms.

The application of the interaction determinant likelihood (IDL) framework to closely related GPCR paralogs demonstrates the emergence of distinct peptide specificities through limited, context-dependent residue substitutions, without significant alterations in overall receptor structure.

A. Shiraishi, H. Satake · General and Comparative Endo... · 0 citations