Author

H. Schulze-Koops

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Open access Nov 2026

Pathogenicity of autoreactive TH17 cells is modulated by the TRPM7 kinase

The melastatin-like transient receptor potential channel, TRPM7, is crucial for signaling in leukocytes. It harbors a channel domain, permeable to divalent cations as well as a serine/threonine α-kinase, phosphorylating inter alia SMAD2. TRPM7 kinase activity is essential for the differentiation of non-pathogenic T hel...

Katharina Jacob, Anna S. Thomann, Anna Madlmayr et al. · bioRxiv · 0 citations

Open access Jul 2026

Comparison of four clinical risk prediction models for the diagnosis of giant cell arteritis: results from the ongoing PREDICT-GCA study

Abstract Background The potential role of structured clinical pretest probability assessment in the diagnostic workup of giant cell arteritis (GCA) is not well defined. Patients and methods We applied four clinical prediction rules to patients enrolled in the ongoing prospective PREDICT GCA study. All patients underwen...

L. Thielmann, C. Lottspeich, L. Reik et al. · RMD Open · 0 citations