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Review Open access Oct 2026

Apical Enlargement, Taper, and Strict Periapical Healing after Primary Endodontic Treatment of Mandibular Molars: A Systematic Review and Exploratory Meta-analysis.

INTRODUCTION This systematic review with exploratory meta-analysis evaluated the association of apical enlargement and taper with strict periapical healing (SPH) after primary endodontic treatment in permanent mandibular molars. METHODS A search to May 18, 2026, was performed using PubMed, Embase, Web of Science, the...

Wei-Hao Shao, K. Takeda, Xu-Jiong Wang et al. · 0 citations
Open access Sep 2026

307. A new nanoformulation of a brain-penetrating VIPR2 antagonist peptide for the treatment of schizophrenia

Abstract Background Both preclinical and clinical studies have demonstrated a strong link between high expression/overactivation of vasoactive intestinal peptide receptor 2 (VIPR2) and schizophrenia. We recently reported on a brain-penetrant formulation of the VIPR2 antagonist peptide KS-133, which was found to restore...

Y. Ago, Z. Jin, D. Koan et al. · 0 citations

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