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H. Shimbo

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Open access Sep 2026

567. cGAS–STING Pathway Activation in Microglia in a Mouse Model of GLUT1 Deficiency Syndrome: Cognitive Improvement with STING Inhibition and a Ketogenic Diet

Abstract Background Glucose transporter type 1 deficiency syndrome (GLUT1-DS) is an inherited metabolic encephalopathy primarily caused by reduced expression and/or function of the GLUT1 protein. A wide range of neurological symptoms, including epilepsy and cognitive impairment, have been reported in affected individua...

N. Aruga, S. Tamura, H. Shimbo et al. · 0 citations

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