Author

H. Sleiman

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Open access Oct 2026

One Scaffold, Many Targets: Fully Modified RNA Nanostructures for Multi-Gene Silencing Beyond the Liver

Therapeutic siRNAs are a major clinical modality for hepatic gene silencing, but efficient extrahepatic delivery and multi-gene modulation remain significant barriers. Nucleic acid nanotechnology offers programmable assembly, but conventional structures suffer from enzymatic instability in vivo. Here we report fully ch...

H. Fakih, Ashley Summers, Qi Tang et al. · bioRxiv · 0 citations

Sep 2026

Beyond Symmetric Motifs: Asymmetric Small-Molecule Recognition Directs a New Poly(adenine) Assembly

DNA/small-molecule hybrid materials provide a powerful route to reprogram nucleic acid structures without covalent modification. However, to date only two small molecules have been shown to direct such assemblies, both relying on symmetric hydrogen-bonding faces. Here, we report that 3-methylxanthine (3MeX), a purine...

Jessica Bennett, Christophe Lachance-Brais, Saleh Almutairi et al. · Journal of the American Chem... · 0 citations

Open access Sep 2026

Expanding the DNA Nanotechnology Toolbox: Hierarchical Assembly and Self-Sorting of DNA Tiles With Precisely Controlled Hydrophobic Behavior.

DNA self-assembly is a powerful strategy to build complex nanostructures, but the chemical uniformity of natural nucleotides limits architectural diversity and long-range organization. Here, we expand the DNA nanotechnology toolbox by integrating tunable hydrophobic effects directly into DNA double-crossover (DX) tiles...

Yi-Hao Wu, Muhammad Ghufran Rafique, Christopher Saab et al. · Angewandte Chemie · 0 citations