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Open access Sep 2026

Integrated clinicogenomic analysis reveals the evolution and metastatic tropisms of advanced colorectal cancer

SUMMARY We performed an integrated clinical and genomic analysis of over 7,000 consecutively sequenced colorectal cancer (CRC) samples to comprehensively characterize genetic drivers and metastatic tropisms of CRC. We find that genomic evolutionary changes, such as clonal mutations and oncogenic mutant allele imbalance...

Paolo Manca, H. Walch, Jierui Xu et al. · 1 citation
Aug 2026

Prognostic and Predictive Effect of Age in Molecularly Defined Lower-Grade Gliomas.

PURPOSE Age ≥40 years is regarded as a high-risk feature and an indication for adjuvant chemoradiotherapy for patients with lower-grade glioma in clinical practice guidelines. It is unclear whether age remains a relevant prognostic factor for contemporary definitions of lower-grade gliomas in the molecular era. METHO...

C. Kinslow, G. Minniti, P. Brown et al. · 0 citations

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