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Review Open access Jul 2026

The Interplay Between Frailty and Alzheimer’s Disease: Pathophysiological Mechanisms, Biomarker Landscapes, and Integrated Therapeutic Strategies

Recognizing frailty and AD as interrelated manifestations of accelerated biological aging provides a critical paradigm shift and developing standardized, high-sensitivity screening tools and dual-target therapeutic strategies will be essential for advancing precision geriatric care and mitigating the global burden of n...

Meirou Liang, Jia-Jun Liu, Yu-Zhe Zhang et al. · 0 citations
Open access Jul 2026

Mind, Mood, and Mobility: Rethinking Functional Disability Prevention in Older Adults on the Basis of a Longitudinal Cohort From CHARLS

Background Disability among older adults in China is becoming an increasing public health challenge due to rapid population aging. We aim to investigate how cognitive deficits, depression, and physical function limitation jointly contribute to the onset and progression of disability. Methods We included 4226 individual...

Lijie Ding, R. Stephen, Maria M. Ekblom et al. · 1 citation

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