Quantitative μ-Opioid Receptor PET with [18F]FCFN in Nonhuman Primates: Naloxone Blockade and Within-Scan Displacement
Background/Objectives: Quantitative PET imaging of μ-opioid receptor (MOR) availability and pharmacologic engagement can advance in vivo studies of opioid receptor biology. We previously evaluated a series of 18F-labeled carfentanil analogs and prioritized the regioisomer [18F]fluorocarfentanil ([18F]FCFN) based on fav...