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Open access Aug 2026

Heparin-calibrated anti-factor Xa activity as a surrogate marker for direct oral anticoagulant levels in acute stroke care: a large observational single-center study

Defined anti-Xa cut-offs are highly specific and sensitive and enable rapid and standardized assessment of anticoagulant activity in this cohort and Heparin-calibrated anti-Xa activity is a reliable surrogate marker for clinically relevant DOAC levels.

M. Büchsel, Katharina Lisko, H. Gölz et al. · 0 citations
Open access Aug 2026

Distinct Multiomic Signatures of Environmental Exposure Drive Immune Dysregulation and Disease Activity in Early Multiple Sclerosis

While smoking cessation must likely be absolute to reverse pathogenic trafficking signals (such as GPR15 upregulation), the linear effect of BMI suggests that incremental weight loss confers proportional immunologic benefits, which strongly support the integration of lifestyle interventions as a core component of early...

Simon Falk, A. Schulte-Mecklenbeck, P. Ostkamp et al. · 0 citations

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