Oct 2026
Vonoprazan attenuates cyclophosphamide-induced ovarian injury in rats via modulation of TLR4/NF-κB and AMPK/SIRT1/Nrf2/HO-1 signaling.
Cyclophosphamide (CPA) is a widely used alkylating agent that causes premature ovarian insufficiency (POI), a major reproductive risk for young female cancer survivors. This study examined whether vonoprazan (VON), a potassium-competitive acid blocker with reported cytoprotective activity in non-gastric tissues, protec...
Al Shaimaa Mahmoud Kotb, Ehab E. Sharata, Reham H. Mohyeldin et al.
· Tissue & Cell · 0 citations