Author

Hae Young Chung

2 papers indexed here

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Open access Sep 2026

Non-chelating 2-(arylthio)acetophenone derivatives as broad-spectrum tyrosinase inhibitors: Synthesis, in silico profiling, in vitro, and in vivo antimelanogenic efficacy.

A series of 2-(arylthio)acetophenone (2-ATAP) derivatives (1-12) were designed and synthesized as novel tyrosinase inhibitors (TYRIs). Among them, five derivatives exhibited superior mushroom tyrosinase (mTYR) inhibitory activities compared to kojic acid, with derivative 5 demonstrating a potent nanomolar IC50 value. D...

Yeonsoo Jeong, Hyunju Lee, Hee-Jin Jung et al. · Bioorganic chemistry (Print) · 0 citations

Open access Aug 2026

MHY5535, a novel PPARα antagonist, sensitizes ovarian cancer stem cells to chemotherapy by disrupting fatty acid oxidation-dependent mitochondrial metabolism.

Ovarian cancer stem cells (CSCs) drive chemoresistance and tumor relapse through metabolic adaptability and enhanced mitochondrial function. Emerging evidence implicates peroxisome proliferator-activated receptor α (PPARα) as a critical regulator of CSC metabolism. Expression profiling and functional analyses revealed...

M. Shin, S. Noh, S. Lee et al. · Biomedicine & pharmacotherap... · 0 citations