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Author

Hai-Dong Dong

2 papers indexed here

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Open access Sep 2026

Targeting SYK enhances responses to radiotherapy and PD-1 blockade with myeloid immune remodeling in breast cancer

Elevated SYK expression, particularly in TNBC, was associated with inferior clinical outcomes and immune dysregulation, and further investigation of SYK-targeted strategies to improve responses to combined radiotherapy and immune checkpoint blockade is supported.

Yi-Qun Han, Qin Zhou, Anna K. Dibbs et al. · 0 citations
Open access Aug 2026

Intracranial Targeting of Cholesterol Processing Reveals a Therapeutic Vulnerability that Reprograms Glioblastoma and Promotes Antitumor Immunity

These findings establish cholesterol dysregulation–induced metabolic collapse as a promising therapeutic approach for GBM using two FDA-approved drugs: the H1 histamine antagonist clemastine and the retinoid X receptor agonist bexarotene.

Maria J. Ulloa-Navas, Rachel M. Whitehead, Vanessa K. Jones et al. · 0 citations

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