Author

Haidun Yan

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Open access Aug 2026

Connectomic dopamine-neuron disinhibition accelerates behavioral extinction

Animals must balance persistence with flexibility when outcomes change. Behavioral extinction—the reduction in responding to cues that no longer predict reward—is widely thought to be driven by pauses in dopamine-neuron firing upon omission of expected rewards. However, whether these pauses are necessary remains unknow...

S. Burwell, Rene Carter, Hai-Dun Yan et al. · bioRxiv · 0 citations

Open access Aug 2026

A cholinergic hub in the nucleus accumbens gates opioid-reward learning

Beneficial and maladaptive opioid effects are difficult to dissociate, partly because dopamine signaling contributes to both. Here we show that associative opioid-reward learning can be blocked even under conditions that elevate dopamine in the nucleus accumbens. We developed naloxoneDART, a cell-type-specific analogue...

S. Yousefzadeh, Haidun Yan, Seung‐Hwa Kwak et al. · Nature · 1 citation