PD16, a steroidal saponin, induces apoptosis in colorectal cancer via inhibiting the AKT/GSK3β signaling pathway.
Colorectal cancer (CRC) is a common malignancy with high morbidity and mortality globally. PD16, a novel steroidal saponin from Paris delavayi Franchet, shows cytotoxicity against HepG2 and U87MG cells, but its anti-CRC effects and related molecular mechanisms remain unknown. Our study revealed that PD16 significantly...