Sep 2026
Effect of metformin on hepatic ischemia-reperfusion injury-induced endoplasmic reticulum stress: A mechanistic exploration based on molecular docking and experimental validation.
Met protects against HIRI by suppressing ER stress, and this effect is associated with GRP78 functional regulation without obvious correction of cytosolic Ca2+ accumulation, suggesting a potential mechanism underlying the hepatoprotective effect of Met.
Ti Zhou, Lian-Qiang Shen, Yao Ma et al.
· Gene · 0 citations