Cancer-associated adipocytes (CAAs) are increasingly recognized as active and heterogeneous components of the tumor microenvironment. Initially defined as tumor-adjacent adipocytes characterized by lipid depletion, reduced expression of mature adipocyte markers, and inflammatory activation, CAAs are now understood to e...
Jin-Dong Xie, Ting-Ting Cai, Neng Wang et al.· Cancer Letters· 0 citations
Immunotherapy has improved outcomes for patients with breast cancer, yet therapeutic resistance remains a major clinical challenge. Therefore, we integrated single-cell and spatial transcriptomic data from breast cancer cohorts treated with immune checkpoint inhibitors to identify resistance-associated cellular populat...
Wei Deng, Yi-Dan Fan, Han-Qi Zhang et al.· Cancer Letters· 0 citations
An overview of current progress in targeted therapies and immunotherapy for breast cancer, highlighting their mechanisms, clinical utility, and challenges is provided.
Song Wu, Pangzhou Chen, Wen Zhou et al.· Chinese Medical Journal· 0 citations
Current evidence on disease burden, etiologic heterogeneity, age-related genomic features, and treatment-relevant tumor immune context in early-onset lung cancer are synthesized, with a focus on issues relevant to clinical interpretation and management prioritization.
Yizhe Wang, Yue-Ge Wang, Yue Pan et al.· Cancer Letters· 0 citations
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