SIL-IS LC-MS/MS method for rapid quantification of phloroglucinol in human plasma: development, validation and application to a pharmacokinetic study.
Phloroglucinol is a smooth muscle relaxant widely used for the symptomatic treatment of gastrointestinal, biliary, and genitourinary spasms. A sensitive, rapid, and robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method incorporating a stable isotope-labeled internal standard (SIL-IS, phloroglucinol-13...