Author

Hai-Xia Zhu

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Review Open access Sep 2026

Beyond local control: radiotherapy–immunotherapy combinations from in situ vaccination to systemic immune remodeling

Background Radiotherapy (RT) is evolving from local cytotoxicity to systemic immunomodulation. Acting as an in situ vaccine, RT initiates antitumor immunity via immunogenic cell death and cGAS-STING activation. However, RT concurrently triggers counter-regulatory immunosuppression—upregulating PD-L1/TGF-β, expanding Tr...

Yu-Long Wen, Nan-Nan Cheng, Sheng Zhou et al. · Frontiers in Genetics · 0 citations

Review Open access Sep 2026

Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review).

Arginine metabolism, polyamine homeostasis and ferroptosis are interconnected molecular processes that influence tumor growth, immune remodeling and therapeutic responses. The availability of arginine is affected by tumor‑cell biosynthesis and uptake, myeloid arginase (ARG)‑mediated depletion, nitric oxide synthase (NO...

Xin-Qiu Dong, Yong-Kun Hou, Jing-Jing Shao et al. · Molecular Medicine Reports · 0 citations