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Open access Sep 2026

Pasteurized Akkermansia muciniphila as a candidate multi-effector pharmacological system in the gut-liver axis: evidence, unresolved causality, and translational priorities

Pasteurized Akkermansia muciniphila is a clinically tractable postbiotic candidate, but its activity cannot be assigned to a single principle. Heat-stable Amuc_1100 is demonstrably retained in pasteurized cells, whereas the GLP-1-inducing protein P9, extracellular vesicles (AmEVs), membrane lipids, and diffusible m...

Yi-Fan Liu, Zi-Hao Xu, Dong-Seon Kim et al. · 0 citations
Review Open access Sep 2026

ALKBH5 inhibitors for cancer therapy: molecular docking, challenges and future prospects

N 6 -Methyladenosine (m 6 A), the most abundant internal modification of eukaryotic mRNA, is dynamically reversed by the Fe II /α-ketoglutarate-dependent dioxygenase ALKBH5, a key m 6 A “eraser” that regulates target mRNA fate through demethylation. ALKBH5 is aberrantly overexpressed in acute myeloid leukemia...

Chen Deng, Hai Xu, Jian Pu et al. · 0 citations

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