The Dual Role of Piezo1 in Cancer: Mechanotransduction, Microenvironment Remodelling, and Therapeutic Opportunities
Abstract The mechanosensitive ion channel Piezo1 translates physical cues from the tumor microenvironment—including extracellular matrix stiffness, fluid shear stress, and compressive forces—into intracellular calcium signals and downstream cascades, playing a pivotal role in cancer. Piezo1 exhibits pronounced tumor-ty...