Hai-Ying Ma

Rational Design and Delivery of Engineered Peptides: Toward a Unified Framework for Structure, Screening, and Application

This review presents a three-tiered engineering framework that systematically addresses these barriers. First, we survey chemical and sequence-based stabilization strategies, including lipidation, backbone N-methylation, and cyclization, that convert labile natural peptides into protease-resistant scaffolds. Second, mo...