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Author

Haiyang Wang

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Open access Oct 2026

Folate metabolism in tumor-associated macrophages drives immunosuppressive function to promote tumor growth

Tumor-associated macrophages (TAMs) promote tumor growth, inhibit effector lymphocytes, and induce resistance to immune checkpoint inhibitors (ICI). Therapies designed to deplete TAMs have had little success in the clinic, and strategies aimed to repolarize immunosuppressive TAMs to pro-inflammatory states have struggl...

Matthew P. Zimmerman, Vasyl Zhabotynsky, Hai-Yang Wang et al. · 0 citations
Open access Aug 2026

Single-cell transcriptomics provides insights into the stress-immune interplay and informs disease risk

An ex vivo model investigating the transcriptomic responses of primary peripheral blood mononuclear cells and neutrophils to physiological stress levels of cortisol and norepinephrine at single-cell resolution provides cell-type-level insights into how stress hormones modulate immune function relevant to human health.

Sofia Benavides, Oksana Kosyk, Haiyang Wang et al. · 1 citation

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