Author

Hakeemah H Al-Nakhle

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Open access Jul 2026

Integrative Clinical and Functional Characterization of the TCF7L2 rs7903146 Variant Reveals Regulatory Mechanisms Linking Genetic Susceptibility to Oxidative Stress in Type 2 Diabetes

Predictive evidence was provided suggesting that rs7903146 may have tissue-specific regulatory relevance and may be indirectly linked to metabolic and WNT/β-catenin signaling pathways, and the proposed regulatory mechanisms require experimental validation.

Ahmed M. Ahmed, Hakeemah H Al-Nakhle, Amjad M. Yousuf et al. · Diagnostics · 0 citations

Open access Aug 2026

Tumor-Intrinsic DNA Damage Signaling Is Associated with MHC-I Expression and CD8 Cytotoxic T-Cell Engagement in Triple-Negative Breast Cancer

An exploratory, integrative analysis using single-cell RNA sequencing of TNBC patients operationally stratified into Good and Bad Prognosis groups suggests a framework in which tumor-intrinsic DNA damage signaling is associated with MHC-I antigen presentation upregulation and CD8 cytotoxic T-cell engagement, supporting further investigation of this axis.

Zinab O. Doha, E. AbuAzzah, Hakeemah H Al-Nakhle · Current Issues in Molecular... · 0 citations