Author

Hal M. Hoffman

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Open access Jul 2026

TRIM21 Orchestrates Inflammasome Assembly and Drives Autoinflammatory Pathology 2300561

These findings establish TRIM21 as a critical regulator of inflammasome assembly and particle release, linking it to the pathogenesis of autoinflammatory disease.

Jessica Carriere, Chawon Yun, Sonal Khare et al. · Journal of Immunology · 0 citations

Open access Aug 2026

Fibroblasts resist Staphylococcus aureus on the skin surface by responding to interleukin-1 and recruiting neutrophils

It is found that fibroblast recognition of interleukin-1 is essential for immune response and fibroblasts actively participate in innate immunity and highlight an IL-1R1–dependent keratinocyte-fibroblast-neutrophil axis of communication.

Jared Simmons, T. Nakatsuji, Feng-Wu Li et al. · Science Advances · 0 citations