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Haley Aull

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Open access Mar 2026

SARS-CoV-2 defective viral genomes from distinct genomic regions drive divergent interferon responses

Defective viral genomes (DVGs) are naturally generated during genomic replication of many RNA viruses. When produced early in infection or supplemented at the onset of infection, DVGs can attenuate viral pathogenesis by stimulating IFN responses and antagonizing wild type (WT) virus replication, highlighting their pote...

Justin W. Brennan, Simone Spandau, Jia-Yu Xu et al. · 0 citations

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