Poly(lactic-co-glycolic acid) (PLGA) nanocarriers can be engineered by varying polymer architecture, particle dimensions, surface chemistry, ligands, coatings, and cargo; however, biological exposure subsequently remodels the interface encountered by cells and tissues. This narrative review examines how this acquired b...
Hamid Omidian, Nazanin Kianinejad, Luigi X. Cubeddu· Current Issues in Molecular...· 0 citations
Myocardial ischemia-reperfusion injury (MIRI) and post-infarction remodeling are characterized by dynamic oxidative stress that varies across myocardial regions and disease stages. Reactive oxygen species (ROS)-responsive and redox-modulating biomaterials seek to exploit this environment through stimulus-triggered rele...
Hamid Omidian, K. Mfoafo, Luigi X. Cubeddu· Frontiers in Drug Delivery· 0 citations
It is argued that the field has moved beyond asking whether RNA can reach the lungs and is best understood as integrated pulmonary products whose success depends on preserving RNA function throughout manufacturing, aerosolization, post-deposition barrier navigation, intracellular delivery, and disease-relevant pharmaco...
The evidence supports a conceptual transition from passive nanocarriers to programmable therapeutic systems capable of aligning therapeutic action with the spatial, temporal, and biological heterogeneity of tumors, but translation remains constrained by formulation complexity, incomplete standardization, limited long-t...
Hamid Omidian, Renae L. Wilson· Frontiers in Bioengineering...· 1 citation
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