Author

Han-Chi Chen

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Open access Sep 2026

Remodeling the Active Site of Sucrose Phosphorylase for Effective Resveratrol Glycosylation.

The plasticity of the enzyme active site is widespread in naturally evolved homologous enzymes, but has been less explored in engineered enzymes. In this study, the plasticity of the active site in sucrose phosphorylases (SPs) for 3-O-α-glucopyranosyl-resveratrol synthesis was obtained. The mutant R135L/Y344Q of BlSP f...

Chang-Xin Lu, Xin Wang, Shuai-Bin Du et al. · Biotechnology and Bioenginee... · 0 citations

Aug 2026

Photoenzymatic Synthesis of l -Alanine with In Situ NADH Regeneration by Alkali Metal-Regulated Carbon Nitride

The efficiency of photoenzymatic catalysis is often constrained by sluggish nicotinamide adenine dinucleotide (phosphate) [NAD(P)H] regeneration and unfavorable interactions among system components. Here, we report an ionic radius-engineered poly(heptazine imide) (PHI) photocatalyst, where Cs+ incorporation directs t...

Le-Qi Xu, Zai-Xiang Xu, Ze-Bin Liu et al. · ACS Catalysis · 0 citations

Open access Oct 2026

Rate-Limiting Enzyme Design in Propionaldehyde Oxidation-Driven Dual-Cofactor Regeneration System

In vitro biomanufacturing offers an efficient platform for green synthesis; however, simultaneous in situ regeneration of NADPH and ATP remains challenging. Herein, a three-enzyme cascade driven by propionaldehyde oxidation is constructed for dual-cofactor regeneration, comprising an engineered NADP+-preferring aldeh...

Ze-Bin Liu, Hui Ren, Yao-Yao Zhao et al. · Chem & Bio Engineering · 0 citations