Author

Han-Ping Shi

2 papers indexed here

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Open access Sep 2026

Glucose-induced histone lactylation confers metformin resistance in colorectal cancer stem cells

Cancer stem cells (CSCs) can adapt their metabolism, which limits the effectiveness of therapies targeting metabolic pathways. Here we show that high glucose conditions promote metformin resistance in CD133⁺ colorectal CSCs by driving a switch from glucose dependence to lipid use. Mechanistically, metformin increases...

Xiangrui Li, Li Deng, Tian-Ge Zhang et al. · Nature Communications · 0 citations

Open access Aug 2026

Multidimensional physiological impairments are associated with frailty and survival in older patients with cancer

Abstract Background and Objectives Frailty, which is influenced by the intricate interactions between malnutrition, metabolism, and systemic inflammation, is highly prevalent in the elderly and constitutes a significant barrier to the effective treatment of older patients with cancer. Assessing specific biomarker patte...

Xiang-Ting Dai, Xi Zhang, Hai-Hong Wang et al. · Journal of Translational Int... · 0 citations